Ann F. Lewis was appointed National Chair of the Women's Vote Center founded by the Democratic National Committee's Women's Leadership Forum (WLF) on February 4, 2002. The Women's Vote Center was formed to educate and mobilize women voters to help elect more Democrats to office at all levels of government.

Lewis enjoyed a busy political career both before and after being appointed to this position. She worked for or advised Boston Mayor Kevin White, Senators Barbara Mikulski and Birch Bayh, and presidential candidate Jesse Jackson. She also served as political director of the Democratic National Committee and as director of Americans for Democratic Action.

During the Clinton Administration, Lewis was the White House Director of Communications from 1997-1999 and Counselor to the President. She was Director of Communications and Deputy Campaign Manager for the Clinton-Gore Re-Election Campaign in 1995-1996.

She served as Senior Advisor to Hillary Rodham Clinton's U.S. Senate campaign in 2000 and as Director of Communications for Friends of Hillary, Senator Hillary Clinton's political action committee, and was active as a senior advisor to Hillary Clinton's 2008 campaign for the Democratic presidential nomination. In June 2009, Lewis was honored with the inaugural National Jewish Democratic Council's Belle Moskowitz Award in Washington, D.C.

While at the White House, Lewis co-chaired the President's Commission on the Celebration of Women in American History. She has also served as a member of the Jewish Women's Archive's Board of Directors and as Chair of JWA's Honorary Committee for the Celebration of 350 Years of Jewish Women in North America.

After the 2008 election, Ann Lewis became president of NoLimits.org,  a non-partisan, non-political organization established to support priorities espoused by Hillary Clinton, including engaging Americans in working with allies around the world to build a safe and secure future.

In 2013, she helped to found the National Jewish Democratic Council's Women's Leadership Network, an issue oriented network devoted to engaging Jewish Democratic women in national politics. “We heard a lot about the women’s vote making a difference in the 2012 election for Democratic candidates,” she said. “We have the same dynamic in the Jewish community, with a significant gender gap, reflective of important issues—but too often Jewish women’s voices were left out of the debate."

See  "The Belle of the Political Ball" and "Jewish Women and the Democratic National Committee," on "Jewsses with Attitude" blog.